Rizal Azis, Wahyu Widowati, Didik Priyandoko, Hanna Sari Widya Kusuma, Dwi Nur Triharsiwi, Aris Muhamad Nurjamil, Vini Ayuni, Dhanar Septyawan Hadiprasetyo, Marisca Evalina Gondokesumo, Nguyen Bao Quoc
Acute Respiratory Distress Syndrome (ARDS) is a severe and potentially life-threatening condition characterized by alveolar-capillary inflammation, leading to lung injury, pulmonary edema, and respiratory failure. Acute Respiratory Distress Syndrome (ARDS) poses a significant challenge in ICUs due to high incidence and high mortality rates, despite advances in medical care. Effective management and treatment strategies are crucial to improving outcomes for patients with ARDS. This study investigates the anti-inflammatory effects of Camellia sinensis L. extract (CSE), rich in epigallocatechin gallate (EGCG), on inflammation-related gene expression in ARDS lung cell model treated with lipopolysaccharide (LPS). Rat alveolar epithelial type II (L2) lung cells induced by LPS were used as the ARDS model and treated with various concentrations of CSE. The gene expressions of CCL-2, CXCL-9, and IFN-g were analyzed by qRT-PCR. CSE treatment decreased expression of pro-inflammatory genes CCL-2, CXCL-9, and IFN-g 1.56 µg/ml CSE concentration (p < 0.05). The results of the study revealed that CSE exhibited potential as an anti-inflammatory agent by inhibiting key inflammatory mediators, suggesting its therapeutic potential in managing ARDS. © 2025, Indian journals. All rights reserved.
Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Biomolecular and Biomedical Research Center, Aretha Medika Utama, Bandung, 40163, Indonesia; Faculty of Medicine, Maranatha Christian University, Bandung, 40164, Indonesia; Biology Study Program, Faculty of Mathematics and Natural Science Education, Universitas Pendidikan Indonesia, Bandung, 40154, Indonesia; Faculty of Pharmacy, Universitas Jenderal Achmad Yani, Cimahi, 40525, Indonesia; Faculty of Pharmacy, University of Surabaya, Surabaya, 60293, Indonesia; Faculty of Biological Sciences, Research Institute of Biotechnology and Environment, Nong Lam University, Ho Chi Minh City, 700000, Viet Nam
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock