D.K. Jasaputra, T. Lucretia, H.R.D. Ray, L. Kwee, D. Gunawan, L. Edwinanto, S.I. Viona, H. Goenawan, R. Lesmana, J.W. Gunadi
Background and Objective: Cardiomyocyte adaptation to exercise might require ROS as a central regulator. There is a limited study regarding the importance of ROS for inducing exercise-induced adaptation and its correlations with changes in histological scoring of cardiac muscles. The study aimed to explore the importance of physiological ROS induced by exercise and its correlation with Cardiomyocyte’ histological appearance that is altered by Moringa oleifera leaves extract in Wistar rats. Materials and Methods: This was an animal experimental study, which use 4 groups of 24 Wistar rats divided into Control (Co), Moringa leaves extract (Mo), Exercise (Ex) and a combination of Moringa leaves extract and Exercise (MoEx). The Moringa leaves extract were given orally, 5 days a week, for 4 consecutive weeks. The exercise was given in moderate intensity, 5 days a week, also for 4 consecutive weeks. Results: This study found significant differences in heart weight and heart weight/body weight ratio in Ex group compared to the control. As for histology scoring, found that MoEx group has 16.7% cardiac hypertrophy and myofiber disarray compared to 83.3%mild hypertrophy and 50% mild disarray in Ex group. Conclusion: In summary, the study showed that the potential central role of exercise-induced physiological ROS for cardiac hypertrophy adaptation is altered by Moringa oleifera leaves extract treatment. © 2022 D.K. Jasaputra et al.
Department of Pharmacology, Faculty of Medicine, Maranatha Christian University, West Java, Bandung, Indonesia; Department of Histology, Faculty of Medicine, Maranatha Christian University, West Java, Bandung, Indonesia; Department of Sport Science, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine, Maranatha Christian University, West Java, Bandung, Indonesia; Department of Physiology, Faculty of Medicine, Maranatha Christian University, West Java, Bandung, Indonesia; Department of Biochemistry, Faculty of Medicine, Maranatha Christian University, West Java, Bandung, Indonesia; Faculty of Medicine, Maranatha Christian University, West Java, Bandung, Indonesia; Physiology Division, Department of Biomedical Sciences, Faculty of Medicine, Universitas Padjadjaran, Indonesia; Physiology Molecular Laboratory, Biological Activity Division, Central Laboratory, Universitas Padjadjaran, Indonesia
Research at a Glance
Register to unlock
Topics & SDG Alignment
Register to unlock
Collaboration
Register to unlock
Author Profile (Selected)
Register to unlock
References Overview
Register to unlock
Journal & Source
Register to unlock
Metadata & Integrity
Register to unlock