Waslaluddin, Wiendartun, Soni Setiadji, Anisa Tri Rahayu, Risdiana
After a successfully identified and synthesized Polydimethylsiloxane known as silicone oil, the product needs to be upgraded and reformulated into a scalable dosage form. The scale-up in producting silicone oil is very important in order to prepare fabrication of silicone oil in large quantity. Here, we reported the synthesis of silicone oil using a duplicated scale to produce silicone oil of the same target quality as a laboratory scale. The dosage was increased twice compare to the previous report. The scale-up of silicone oil samples with viscosity values of 1700-2920 mPa.s has been successfully synthesized from Octamethylcyclotetrasiloxane (D4) as monomer and Hexamethyldisiloxane (MM) as terminator using ring-opening polymerization method. From FTIR spectroscopy, it was found that all the samples synthesized with double dosage had a structure and functional groups similar to commercial PDMS. From the refractometer and surfgauge measurements, the scale-up sample has a refractive index in between 1.4026 and 1.4038 and a surface tension value from 19.0 to 20.0 m.N/m. © 2021 Trans Tech Publications Ltd, Switzerland.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang km 21 Jatinangor, Sumedang, West Java, 45363, Indonesia; Department of Physics Education, Faculty of Mathematics and Natural Sciences Education, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudi No. 229, Isola, Sukasari, Bandung, West Java, 40154, Indonesia; Department of Chemistry, Faculty of Science and Technology, UIN Sunan Gunung Djati Bandung, Jl. A. H. Nasution No. 105 Cibiru, Bandung, West Java, 40614, Indonesia; Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang km 21 Jatinangor, Sumedang, West Java, 45363, Indonesia
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