Effect of oral administration of tungsten trioxide (wo3) particles on hispathological feature of liver and kidney in rat

H.S.H. Munawaroh; A.B.D. Nandiyanto; G.G. Gumilar; A. Widi; M. Subangkit

doi:10.1088/1757-899X/180/1/012097

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Effect of oral administration of tungsten trioxide (wo3) particles on hispathological feature of liver and kidney in rat

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H.S.H. Munawaroh, A.B.D. Nandiyanto, G.G. Gumilar, A. Widi, M. Subangkit

2017 IOP Conference Series: Materials Science and Engineering Vol. 180 Issue 1 Conference paper Cited by 4 SDG 3

Abstract

This study aims to investigate the toxicity and histopathology of tungsten trioxide (WO3) administration on rat's liver and kidney. The LD50 of WO3 was determined and the sub acute toxicity was evaluated by orally administration of 5000 mg kg-1 of WO3 to rat for 14 consecutive days. Parameter of blood cells, ALT, creatinine, and BUN were experimentally measured. The toxicological evaluation showed that WO3 is a non toxic compound with the LD50 higher that 5000 mg kg-1. No biochemical change was observed for creatinine and Blood Urea Nitrogen parameter. In contrast, ALT parameter shows higher value in the experiment than that in the control group. Histopathological changes on rat's liver and kidney were also studied. Small defects in rat's liver and kidney were found, which may interfere the functional of related enzymes. © Published under licence by IOP Publishing Ltd.

Affiliations

Departemen Kimia, FPMIPA, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi No. 229, Jawa Barat, 40154, Indonesia; Fakultas Kedokteran Hewan, Institut Pertanian Bogor, Kampus IPB Darmaga, Jl. Agatis, Jawa Barat, Bogor, Indonesia

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