Iqbal Musthapa, Euis H. Hakim, Yana M. Syah, Lia D. Juliawaty
The methanol extract of the heartwood of Artocarpus heterophyllus were purified using several chromatography tehnique to give eleven flavonoid compunds: Gemichalcone A (1), gemichalcone B (2), norartocarpanone (3), artocarpanone (4), dihydromorin (5), norartocarpetin (6), artocarpesin (7),cycloartocarpesin (8), cudraflavone C (9), artocarpin (10), and cycloartocarpin (11). The structure of these compounds established by spectroscopic mean and by comparison with the literature values. Compound 10, exhibited very strong (IC50 < 2,0 μg/mL), whereas compounds 2 and 9 showed strong inhibition (IC50 2,1-4,0 μg/mL) against P-388 cell lines. © 2006-2016 Asian Research Publishing Network (ARPN). All rights reserved.
Organic Division, Chemistry Department, Universitas Pendidikan Indonesia, Jl. Dr. Setiabudhi Bandung, Indonesia; Organic Division, Chemistry Department, Institut Teknologi Bandung, Jl. Ganeca, Bandung, Indonesia
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