Kartika Yulianti, Agus Y. Gunawan
Oxygen plays an important role in the metabolism of cells inside the human body. The transfer of oxygen from blood to tissue takes place in capillaries through a diffusion process. The capillary-tissue region is usually represented by the so-called Krogh cylinder model, in which the distribution of the oxygen concentration in a tissue region leads to a diffusion equation with oxygen consumption rates following the Michaelis-Menten kinetics. In this paper, we restrict ourselves to the steady state case and solve the equation analytically by means of asymptotic expansion for a particular limit of the oxygen consumption rate. Results show that there exists a critical ratio between supply and consumption of oxygen in the tissue region in order to fulfill the cell's oxygen requirements. Above from this critical ratio, we also found a critical distance in the tissue region above which the oxygen concentration vanishes. We compared our asymptotic results with numerical simulations, which turned out to be quite in agreement. © 2012 Published by LPPM ITB.
Department of Mathematics Education, Indonesia University of Education (UPI), Bandung, Jawa Barat 40154, Jalan Dr. Setiabudhi No. 229, Indonesia; Industrial and Financial Mathematics Research Group, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Bandung, Jawa Barat 40132, Jalan Ganesha 10, Indonesia
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